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Holistic Integrative Oncology（HIO，eISSN:2731-4529; CN12-1481/R73）是由中国9I制作厂免费与Springer Nature出版集团于2021年强强联合打造的一本英文大刊，主编为中国9I制作厂免费理事长樊代明院士。HIO入选了2022年中国科技期刊卓越行动计划高起点新刊项目，是面向全球开放的自由获取同行评议期刊，设有CACA指南、专家述评、研究综述和原创论著等栏目。肿瘤基因诊断专题文章已正式上线，敬请各位读者阅读、引用与分享！
本专题目录
01 CACA Technical guidelines for holistic integrative management of cancer —— genetic testing
文章类型：Guideline
引用格式：CACA –Committee of Cancer Genetic Diagnosis., Wei, B., Xing, J. et al. CACA Technical guidelines for holistic integrative management of cancer —— genetic testing. Holist Integ Oncol 4, 14 (2025). https://doi.org/10.1007/s44178-025-00149-5
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02 Pathological mechanisms and advances in neoadjuvant PD-1 blockade combined with chemotherapy for head and neck cancer
文章类型：Commentary
引用格式：Hou, Yj., Yang, Xx. & Meng, Hx. Pathological mechanisms and advances in neoadjuvant PD-1 blockade combined with chemotherapy for head and neck cancer. Holist Integ Oncol 3, 63 (2024). https://doi.org/10.1007/s44178-024-00140-6
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03 Role in development or treatment of LEF1-AS1 in tumors of the digestive system
文章类型：Review
引用格式：Ma, H., Li, L., Jiang, C. et al. Role in development or treatment of LEF1-AS1 in tumors of the digestive system. Holist Integ Oncol 4, 13 (2025). https://doi.org/10.1007/s44178-025-00150-y
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04 Effectiveness of auricular acupoint therapy on chemotherapy-induced gastrointestinal reaction in breast cancer patients: a systematic review and meta-analysis
文章类型：Review
引用格式：Chen, K., Zhang, N. & Ye, T. Effectiveness of auricular acupoint therapy on chemotherapy-induced gastrointestinal reaction in breast cancer patients: a systematic review and meta-analysis. Holist Integ Oncol 3, 67 (2024). https://doi.org/10.1007/s44178-024-00147-z
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05 Combining immunogenic cell death and cuproptosis to construct a prognostic signature and predict the immune status and treatment efficacy for hepatocellular carcinoma
文章类型：Original Research
引用格式：Feng, X., Li, X. & Zhang, X. Combining immunogenic cell death and cuproptosis to construct a prognostic signature and predict the immune status and treatment efficacy for hepatocellular carcinoma. Holist Integ Oncol 3, 65 (2024). https://doi.org/10.1007/s44178-024-00143-3
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06 Profiling of driver mutations in lung adenocarcinoma patients identifies rare compound EGFR mutations sensitive to second-generation EGFR-TKIs
文章类型：Original Research
引用格式：Li, J., Zhang, C., Guan, Y. et al. Profiling of driver mutations in lung adenocarcinoma patients identifies rare compound EGFR mutations sensitive to second-generation EGFR-TKIs. Holist Integ Oncol 3, 64 (2024). https://doi.org/10.1007/s44178-024-00139-z
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07 Expression and correlation of Surfeit 4 gene in esophageal squamous cell carcinoma
文章类型：Original Research
引用格式：Liu, Jx., Lu, T., Xia, Y. et al. Expression and correlation of Surfeit 4 gene in esophageal squamous cell carcinoma. Holist Integ Oncol 3, 66 (2024). https://doi.org/10.1007/s44178-024-00141-5
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08 Extrachromosomal circular DNA: enlightenment to widespread clinical application
文章类型：Short Communication
引用格式：Wang, S., Li, H., Zhang, Y. et al. Extrachromosomal circular DNA: enlightenment
to widespread clinical application. Holist Integ Oncol 4, 8 (2025). https://doi.org/10.1007/s44178-025-00151-x
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